TECHNOLOGY OVERVIEW

LamdaGen's patented LSPR (localized surface plasmon resonance) technology platform utilizes an advanced optical method to identify specific molecular interactions of non-labeled molecules such as DNA, RNA, proteins or low molecular weight compounds. The Company’s instruments provide rapid, real-time results for protein quantification and characterization of protein-protein interactions. Our various LSPR systems enable real-time analysis of bio-molecular interactions in micro-volume sample sizes providing precise information on affinity, kinetics or concentration with high sensitivity.

Precise Nanostructure Fabrication for Optimum Optical Response

Substrate Production

The various LSPR producing substrate composites utilized by LamdaGen are characterized by a variety of unique physical, optical, and electrical properties that can be precisely controlled and tuned for specific uses. By carefully structuring its patented surfaces, LamdaGen controls the emission of light to specific wavelengths. This calibration throughout the IR to UV spectrums has significant practical use in a number of specific applications, including highly sensitive and robust real-time monitoring/analysis of molecular binding events, biological fluids, cells and tissue chemistries.

SPR:

SPR (surface plasmon resonance) detection is based on the measurement of the angle at which light is reflected from the side of a sensor surface that is not in contact with a sample.

In contrast, LamdaGen's LSPR technology does not depend on the angle of incident light change and the associated disadvantages of strict temperature control and the requirement of accurately detecting minimal optical changes. LamdaGen's instruments instead rely on wavelength shift in adsorption caused by the binding event of a target molecule on its LSPR surface. This allows LamdaGen to monitor label-free molecular interactions by simply measuring optical changes in adsorption, providing a robust signal that offers significant performance advantages in robustness, size, costs, mobility, and user friendliness as compared to traditional SPR devices.

LamdaGen's products include the four-channel Light-Path system (in commercial beta test) and the Company’s hand-held appliance (in alpha test). Both provide real-time measurement of non-labeled molecular binding events.

Applications include:

• Life science research
• Drug discovery and development
• Bio-detection
• Point-of-care diagnostics
• Environmental monitoring
• Fermentation monitoring
• Soils analysis
• Food quality and analysis