TECHNOLOGY OVERVIEW

LamdaGen's patented E-LSPR (Enhanced localized surface plasmon resonance) technology platform utilizes an advanced optical method to identify specific molecular interactions of non-labeled molecules such as DNA, RNA, proteins or low molecular weight compounds. The Company’s instruments provide rapid, real-time results for protein quantification and characterization of protein-protein interactions. Our various E-LSPR systems enable real-time analysis of bio-molecular interactions in micro-volume sample sizes providing precise information on affinity, kinetics or concentration with high sensitivity.

At the Core of LamdaGen’s Label Free Analytical Bench-Top, LightPath System, is the Company’s P-4 protein chip.

Bringing new levels of sensitivity to
label-free analytics

The various E-LSPR producing substrate composites utilized by LamdaGen are characterized by a variety of unique physical, optical, and electrical properties that can be precisely controlled and tuned for specific uses. By carefully structuring its patented surfaces, LamdaGen controls the emission of light to specific wavelengths. This calibration throughout the IR to UV spectrums has significant practical use in a number of specific applications, including highly sensitive and robust real-time monitoring/analysis of molecular binding events.

What is Enhanced Localized Surface Plasmon Resonance (E-LSPR)?

LamdaGen has developed a proprietary process to reproducibly manufacture metallic film with nanometer-scale features. These patented surfaces exhibit remarkable optical properties. The technology is simple and utilizes white light to activate the nanostructured film where absorption occurs and the light loses its yellow-orange components, with the remaining light reflecting back from the surface. This reflectivity spectrum of the nano-film is then measured with a spectrophotometer or other optical reader.

The strong interaction between light and the nanostructured surface is responsible for the intense burgundy color of LamdaGen’s standard surfaces even though our nano-films are made of gold (or other metals).  The strongest interaction is observed for a particular wavelength, called “lambda min” as illustrated below.

The origin of the interaction resides in the ability of our nanostructured surfaces to sustain very intense enhanced localized surface plasmons when activated by light. The Company’s patented nano-fabrication process enables the LSPR to be amplified via a cooperative plasmon effect that increases sensor robustness significantly, i.e. termed E-LSPR.

Applications include:

• Life science research
• Drug discovery and development
• Point-of-care diagnostics
• Bio-process monitoring